thromboxane receptor การใช้

• Picotamide has activity both as a thromboxane synthase inhibitor and as a thromboxane receptor antagonist.
• The gene responsible for the thromboxane receptor, TBXA2R is found on chromosome 19 and spans 15 kilobases.
• It works as a thromboxane synthase inhibitor and a thromboxane receptor inhibitor, the latter by modifying cellular responses to activation of the thromboxane receptor.
• It works as a thromboxane synthase inhibitor and a thromboxane receptor inhibitor, the latter by modifying cellular responses to activation of the thromboxane receptor.
• Lack of IL-10 has been shown to cause COX activation and resultant Thromboxane receptor activation to cause vascular endothelial and cardiac dysfunctions in mice.
• 12 ( " S " )-HETE and 12 ( " R " )-HETE bind to and act as Competitive antagonists of the Thromboxane receptor which mediates the actions of Thromboxane A2 and Prostaglandin H2.
• One or both of these compounds stimulates cells by binding with and activating two G protein-coupled receptors, GPR31 and the Leukotriene B4 receptor 2; 12 " S "-HETE also acts as a receptor antagonist by binding to but not stimulating the Thromboxane receptor thereby inhibiting the actions of Thromboxane A2 and Prostaglandin H2 ( see 12-Hydroxyeicosatetraenoic acid # Receptor targets and mechanisms of action ).